4E-BP functions as a metabolic brake used under stress conditions but not during normal growth

Article Abstract:

The relevance of 4E-BP function, an important regulator of overall translation levels in cells, for organismal development is discussed and evidence for an alternate view is presented. It is suggested that 4E-BP works as a metabolic break that is activated under conditions of environmental stress to control fat metabolism.

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Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth

Article Abstract:

The Drosophila Sterile-20 kinase Slik promotes tissue growth during development by stimulating cell proliferation and by preventing apoptosis. It is observed that Slik acts via distinct pathways to coordinate cell proliferation with epithelial cell behavior during tissue growth.

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Denoising feedback loops by thresholding - A new role for microRNAs

Article Abstract:

Post-transcriptional gene regulation by the microRNA miR9a plays an important role in ensuring the precision of sense organ specification in Drosophila. The function of miR-9a is reported by generating a targeted knockout of a precursor hairpin in Drosophila melanogaster.

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