24p3 and its receptor: Dawn of a new iron age?

Article Abstract:

The cloning of the receptor for 24p3 called 24p3R is described and the DNA sequence of this molecule matched a database entry proposed to encode a murine braintype organic cation transporter. This molecule is highly conserved in humans and is predicted to have twelve transmembrane helices, suggesting a link between iron internalization mediated by 24p3R and the regulation of apoptosis.

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Caspase-1 builds a new barrier to infection

Article Abstract:

A new strategy for host defense in which caspase-1 promotes cell survival by activating a pathway that repairs the cellular damage inflicted by pore forming toxins is reported. Upon activation, caspase-1 processes the pro-inflammatory cytokines IL-1[beta] and IL-18, leading to their secretion, which contributes to the innate immune response and host defense.

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The inflammasome: First line of the immune response to cell stress

Article Abstract:

NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. New insights into the regulation of caspase-1 activity in the inflammatory response are discussed.

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