Article Abstract:
A study was conducted to demonstrate that Saccharomyces cerevisiae 14-3-3 homologs is significant for RAS/MAPK cascade signaling during pseudohyphal development. Results reveal that RAS2 and CDC42's activated alleles can cause pseudohyphal development. Furthermore, the process can significantly affect FG(TyA)-lacZ signaling exhibited by Bmh+ strains. Alleles of BMH1 complement other 14-3-3 functions, making 14-3-3 proteins a requirement in RAS/MAPK cascade signaling in pseudohyphal development in S. cerevisiae.
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Article Abstract:
A study was conducted to analyze the association of Nmi, a protein reported as an N-Myc interactor. The function of Nmi in Interleukin-2-responsive YT cells was also examined. Experimental results indicated that the protein can potentiate transcription and augment coactivator protein recruitment to members of a group of sequence-specific transcription factors. Findings also showed that Nmi lacks an intrinsic inactivation domain.
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Article Abstract:
Candida albicans, a fungal pathogen, can change from a yeast to a filamentous form. Two regulatory proteins Ste12p and Phd1p regulate the change in Saccharomyces. Single-mutant strains are partly defective, whereas the double mutant is entirely defective and noninvasive in filamentous growth. In a mouse model, the Candida cph1/chh1 efg1/efg1 double mutant in the yeast form, was found to be avirulent.
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